Location History:
- Philadelphia, PA (US) (2016 - 2019)
- Rahway, NJ (US) (2020)
Company Filing History:
Years Active: 2016-2020
Title: Marshall J Levesque: Innovator in Genetic Detection Technologies
Introduction
Marshall J Levesque is a prominent inventor based in Philadelphia, PA (US). He has made significant contributions to the field of genetic detection, holding a total of 3 patents. His work focuses on innovative methods for analyzing genetic material at the single-cell level, which has important implications for research and medical diagnostics.
Latest Patents
One of his latest patents is a "Method for detecting mutations in single cells or single molecules." This invention provides a high-efficiency fluorescence in situ hybridization (FISH) method for detecting mutations on individual RNA transcripts, including both exonic and intronic RNA transcripts. In certain embodiments, the method is used to quantify allelic expression at the population and single-cell level, and also to distinguish maternal chromosomes from paternal chromosomes in single cells.
Another notable patent is the "Method for detecting chromosome structure and gene expression simultaneously in single cells." This invention relates to systems and methods for measuring chromosome structure and gene expression. In one embodiment, it includes an assay for determining the spatial organization of gene expression in the nucleus. The method based on fluorescence in situ hybridization (FISH) simultaneously yields information on the physical position and expression of individual genes. By lighting up a large number of targets on a particular chromosome using a bar-coding scheme, the large-scale structure of an entire chromosome can be determined.
Career Highlights
Marshall has worked at prestigious institutions such as the University of Pennsylvania and the University of California. His research has significantly advanced the understanding of genetic structures and their functions.
Collaborations
He has collaborated with notable colleagues, including Arjun Raj and Jason H Haga, contributing to various research projects that enhance the field of genetic analysis.
Conclusion
Marshall J Levesque's innovative work in genetic detection technologies has paved the way for advancements in understanding genetic mutations and expressions. His contributions are vital for both research and clinical applications, showcasing the importance of innovation in the scientific community.