The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 2016
Filed:
Mar. 15, 2012
Jason H. Haga, San Diego, CA (US);
Shu Chien, La Jolla, CA (US);
Matt Mui, La Jolla, CA (US);
Marshall J. Levesque, Philadelphia, PA (US);
Phillip D. Pham, San Francisco, CA (US);
Jason H. Haga, San Diego, CA (US);
Shu Chien, La Jolla, CA (US);
Matt Mui, La Jolla, CA (US);
Marshall J. Levesque, Philadelphia, PA (US);
Phillip D. Pham, San Francisco, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
In alternative embodiments, the invention provides compositions that inhibit the polypeptide SSH-2, or SlingSHot-2, a phosphatase enzyme that regulates actin filaments, and methods for making and using them, including methods comprising administering compositions of the invention to regulate or modify actin filament polymerization by inhibiting SSH-2, where in one embodiment compositions of the invention slow or inhibit F-actin depolymerization and severing. In alternative embodiments, compositions and methods of the invention are used to slow or inhibit cell motility and/or internal remodeling. In alternative embodiments, compositions and methods of the invention are used to slow or inhibit, or reverse, or ameliorate the progression of a cancer or a metastasis or other uncontrolled or unregulated cell growth, and/or Alzheimer's disease.