Mark William Budde

Title: Innovations of Mark William Budde

Introduction

Mark William Budde is an accomplished inventor based in Arcadia, CA, with a notable portfolio of six patents. His work primarily focuses on synthetic systems and methods that enhance the understanding and treatment of biological processes.

Latest Patents

Among his latest patents is a synthetic system for tunable thresholding of protein signals. This invention includes methods, compositions, and kits that are suitable for thresholding protein signals. The synthetic protein circuits he developed respond to inputs only above or below a certain threshold concentration, with the threshold value being tunable in some embodiments. Additionally, he has provided methods for treating diseases characterized by aberrant signaling.

Another significant patent is for synthetic mammalian signaling circuits that enable robust cell population control. This invention includes circuits, compositions, nucleic acids, and methods that allow cells to sense and respond to their own population size. In some embodiments, an orthogonal communication channel facilitates specific communication between engineered cells. The architecture of the regulatory circuit is designed to stimulate and inhibit net cell growth at different signal concentrations, allowing engineered cells to autonomously reach designed densities.

Career Highlights

Mark William Budde is affiliated with the California Institute of Technology, where he contributes to groundbreaking research and innovation in synthetic biology. His work has implications for both scientific understanding and practical applications in medicine.

Collaborations

He has collaborated with notable colleagues, including Michael B Elowitz and Lucy S Chong, who are also recognized for their contributions to the field of synthetic biology.

Conclusion

Mark William Budde's innovative work in synthetic systems and signaling circuits showcases his significant contributions to the field of biology and medicine. His patents reflect a commitment to advancing scientific knowledge and developing practical solutions for complex biological challenges.