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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11667676 B1

PDFFull Text
Date of Patent:
Jun. 06, 2023

Filed:

Jan. 09, 2020

Synthetic system for tunable thresholding of protein signals

Applicant:

California Institute of Technology, Pasadena, CA (US);

Inventors:

Lucy S. Chong, Pasadena, CA (US);

Ronghui Zhu, Pasadena, CA (US);

Xiaofei Ge, Beijing, CN;

Michael B. Elowitz, Pasadena, CA (US);

Mark W. Budde, Arcadia, CA (US);

Assignee:

California Institute of Technology, Pasadena, CA (US);

Attorney:

Sheppard, Mullin, Richter & Hampton LLP

Primary Examiner:

Aradhana Sasan

Assistant Examiner:

Mercy H Sabila

Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 14/00 (2006.01); C12N 9/22 (2006.01);
U.S. Cl.
CPC ...
C07K 14/001 (2013.01); C12N 9/22 (2013.01);
Abstract

Disclosed herein include methods, compositions, and kits suitable for use in thresholding of protein signals. There are provided, in some embodiments, synthetic protein circuits that respond to inputs only above or below a certain threshold concentration. In some embodiments, the threshold value itself is tunable. Methods of treating a disease or disorder characterized by aberrant signaling are provided in some embodiments.

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Quick Actions:

Chong, Lucy. (2023). Synthetic system for tunable thresholding of protein signals (U.S. Patent No. 11667676). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11667676

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