The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2023
Filed:
Jan. 09, 2020
Applicant:
California Institute of Technology, Pasadena, CA (US);
Inventors:
Lucy S. Chong, Pasadena, CA (US);
Ronghui Zhu, Pasadena, CA (US);
Xiaofei Ge, Beijing, CN;
Michael B. Elowitz, Pasadena, CA (US);
Mark W. Budde, Arcadia, CA (US);
Assignee:
California Institute of Technology, Pasadena, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 14/00 (2006.01); C12N 9/22 (2006.01);
U.S. Cl.
CPC ...
C07K 14/001 (2013.01); C12N 9/22 (2013.01);
Abstract
Disclosed herein include methods, compositions, and kits suitable for use in thresholding of protein signals. There are provided, in some embodiments, synthetic protein circuits that respond to inputs only above or below a certain threshold concentration. In some embodiments, the threshold value itself is tunable. Methods of treating a disease or disorder characterized by aberrant signaling are provided in some embodiments.