Location History:
- North Hills, CA (US) (2018)
- Norwalk, CA (US) (2018)
Company Filing History:
Years Active: 2018
Title: Mark Saul Lazari: Innovator in Automated Radio-Synthesis
Introduction
Mark Saul Lazari is a notable inventor based in Norwalk, California. He has made significant contributions to the field of automated radio-synthesis, holding a total of 3 patents. His work focuses on developing advanced technologies that enhance the production of pet tracers for clinical use.
Latest Patents
One of Lazari's latest patents is an "Automated, multi-pot high-pressure radio-synthesizer for production of pet tracers." This innovative device features multiple reactor assemblies that are operatively connected to horizontal and vertical actuators. These actuators allow for precise movement of the reactor assemblies. The device also includes disposable cassettes equipped with sealed and un-sealed gaskets, which are integral to the internal fluid paths. Additionally, a three-axis reagent and gas handling robot is incorporated, enhancing the efficiency of the synthesis process. This automated system has demonstrated the capability to synthesize clinically relevant amounts of 16β-F-fluoro-5α-dihydrotestosterone (F-FDHT) in just 90 minutes, achieving a decay-corrected radiochemical yield of 29±5%. The specific activity at the end of formulation was 4.6 Ci/μmol, providing sufficient activity for multiple patient doses while passing all necessary quality control tests.
Career Highlights
Lazari's career is marked by his dedication to advancing medical technology through innovative solutions. His work at the University of California has positioned him as a leader in the field of radio-synthesis. His inventions have not only contributed to scientific knowledge but have also had a direct impact on clinical practices.
Collaborations
Throughout his career, Lazari has collaborated with esteemed colleagues, including Melissa Moore and R. Michael Van Dam. These partnerships have fostered a collaborative environment that encourages innovation and the sharing of ideas.
Conclusion
Mark Saul Lazari's contributions to automated radio-synthesis exemplify the spirit of innovation in the medical field. His patents and collaborative efforts continue to pave the way for advancements in clinical applications.