The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 04, 2018

Filed:

Feb. 03, 2016
Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Jennifer Marie Murphy, Los Angeles, CA (US);

Mark Saul Lazari, Norwalk, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07J 75/00 (2006.01); B01J 19/00 (2006.01); C07J 31/00 (2006.01); C07J 21/00 (2006.01); C07J 1/00 (2006.01);
U.S. Cl.
CPC ...
C07J 31/006 (2013.01); B01J 19/004 (2013.01); B01J 19/0093 (2013.01); C07J 1/0022 (2013.01); C07J 21/006 (2013.01); B01J 2219/00813 (2013.01); B01J 2219/00889 (2013.01); C07J 75/00 (2013.01);
Abstract

The automated synthesis of clinically relevant amounts of 16β-F-fluoro-5α-dihydrotestosterone (F-FDHT) using a commercially available radiosynthesizer. Synthesis was performed in 90 minutes with a decay-corrected radiochemical yield of 29±5%. The specific activity was 4.6 Ci/μmol (170 GBq/μmol) at end of formulation with a starting activity of 1.0 Ci (37 GBq). The formulatedF-FDHT yielded sufficient activity for multiple patient doses and passed all quality control tests required for routine clinical use.


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