Mark R Krystal

Title: The Innovations of Mark R. Krystal

Introduction

Mark R. Krystal is a notable inventor based in Westport, CT, with a significant contribution to the field of pharmaceuticals. He holds a total of 8 patents, showcasing his innovative approach to addressing complex medical challenges. His work primarily focuses on developing compounds that can inhibit HIV integrase, which is crucial for treating HIV infections and AIDS.

Latest Patents

One of his latest patents is titled N-[[4-fluoro-2-(5-methy-1H-1,2,4-triazol-1-yl)phenyl]methyl]-4-,6,7,9-tetrahydro-3-hydroxy-9,9-dimethyl-4-oxo-pyrimido[2,1-c][1,4]oxazine-2-carboxamide. This invention encompasses a series of bicyclic pyrimidinone compounds that inhibit HIV integrase, preventing viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. Another significant patent involves recombinant negative-strand RNA virus expression systems and vaccines. This patent describes recombinant negative-strand viral RNA templates that can be used with purified RNA-directed RNA polymerase complex to express heterologous gene products in appropriate host cells.

Career Highlights

Throughout his career, Mark R. Krystal has worked with prominent companies such as Bristol-Myers Squibb Company and MedImmune Vaccines, Inc. His experience in these organizations has allowed him to contribute to groundbreaking research and development in the pharmaceutical industry.

Collaborations

Mark has collaborated with notable individuals in his field, including B. Narasimhulu Naidu and Jacques Banville. These collaborations have further enriched his research and innovation efforts.

Conclusion

Mark R. Krystal's contributions to the field of pharmaceuticals through his patents and collaborations highlight his dedication to advancing medical science. His innovative work continues to play a vital role in the fight against HIV and other viral infections.