North Wales, PA, United States of America

Mark E Fraley

This inventor holds 70 USPTO granted patents and 13 published patent applications, plus 1 CIPO patent and 15 EPO patents, primarily in CGRP Receptor Antagonists (CPC class C07D). Top assignees: Merck + Co., Inc., Merck Sharp + Dohme Corp., Merck Sharp & Dohme LLC. Active years: 1997-2026.

USPTO Granted Patents = 70 (Patent Applications = 13)

% Patents Active = 48.6

CIPO Patents = 1 (Patent Applications = 3)

EPO Patents = 15 (Patent Applications = 21)

Average Co-Inventor Count = 3.9

ph-index = 17

Forward Citations = 777(Granted Patents)

Forward Citations (Not Self Cited) = 721(Dec 10, 2025)

Inventors with similar research interests:

Location History:

North Wales, NJ (US) (2006)
West Point, PA (US) (2015)
North Wales, PA (US) (1997 - 2021)

Company Filing History:

Merck Sharp + Dohme Corp.

patents

2 out of 64

Merck Sharp & Dohme LLC

patents

where one patent can have more than one assignee

Years Active: 1997-2026

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Areas of Expertise:

CGRP Receptor Antagonists

Mitotic Kinesin Inhibitors

Kinase Inhibitors

Glucosylceramide Synthase Inhibitors

Histone Deacetylase Inhibitors

AHCY Hydrolase Inhibitors

Orexin Receptor Antagonists

Positive Allosteric Modulators

Spirolactam Compounds

Pyrazolo[1,5-A]Pyrimidines

Checkpoint Kinase Inhibitors

Therapeutic Compositions

70 patents (USPTO):Sort by Forward CitationsExplore Patents

1. 12679807 - Modified isoindolinones as glucosylceramide synthase inhibitors (2026-07-14),

2. 12559491 - Modified imidazopyridines as glucosylceramide synthase inhibitors (2026-02-24),

3. 11066396 - 3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors (2021-07-20),

4. 10272077 - Piperidinone carboxamide azaindane CGRP receptor antagonists (2019-04-30),

5. 9914736 - TrKA kinase inhibitors, compositions and methods thereof (2018-03-13),

6. 9862716 - TRKA kinase inhibitors, compositions and methods thereof (2018-01-09),

7. 9833448 - Piperidinone carboxamide azaindane CGRP receptor antagonists (2017-12-05),

8. 9815846 - TrkA kinase inhibitors, compositions and methods thereof (2017-11-14),

9. 9499545 - Piperidinone carboxamide azaindane CGRP receptor antagonists (2016-11-22),

10. 9499541 - Piperidinone carboxamide indane CGRP receptor antagonists (2016-11-22),

11. 9296750 - Spirolactam CGRP receptor antagonists (2016-03-29),

12. 9227973 - Pyridine CGRP receptor antagonists (2016-01-05),

13. 9227972 - Aliphatic spirolactam CGRP receptor antagonists (2016-01-05),

14. 8993779 - Positive allosteric modulators of MGLUR2 (2015-03-31),

15. 8975286 - Ether benzotriazole derivatives (2015-03-10),

Title: Mark E Fraley - Pioneering Inventor from North Wales, PA

Introduction: Mark E Fraley is a distinguished inventor hailing from North Wales, PA, known for his groundbreaking contributions to various fields.

Latest Patents: Mark E Fraley holds several patents in the areas of technology, healthcare, and consumer products, showcasing his versatility and innovative spirit.

Career Highlights: Throughout his illustrious career, Mark E Fraley has been recognized for his inventive prowess, receiving accolades for his cutting-edge solutions that have positively impacted industries worldwide.

Collaborations: Mark E Fraley has collaborated with leading companies, research institutions, and universities to bring his ideas to life, fostering a culture of innovation and excellence in every project.

Conclusion: Mark E Fraley's dedication to innovation and his relentless pursuit of excellence continue to inspire the next generation of inventors, leaving an indelible mark on the world of technology and beyond.