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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12679807 B1

PDFFull Text
Date of Patent:
Jul. 14, 2026

Filed:

Nov. 18, 2021

Modified isoindolinones as glucosylceramide synthase inhibitors

Applicant:

Merck Sharp & Dohme Llc, Rahway, NJ (US);

Inventors:

Michael J. Breslin, Drexel Hill, PA (US);

Mark E. Fraley, North Wales, PA (US);

H. Marie Loughran, Perkasie, PA (US);

James J. Mulhearn, Elkins Park, PA (US);

Anthony J. Roecker, Harleysville, PA (US);

Kathy M. Schirripa, Harleysville, PA (US);

Shawn J. Stachel, Perkasie, PA (US);

Assignee:

Merck Sharp & Dohme LLC, Rahway, NJ (US);

Attorneys:

Patricia A. Shatynski

John C. Todaro

Primary Examiner:

Jennifer A Berrios

Assistant Examiner:

Sophia undefined Reilly

Int. Cl.
CPC ...
C07D 209/34 (2006.01); A61K 45/06 (2006.01); A61P 25/16 (2006.01); C07D 401/12 (2006.01); C07D 403/04 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 405/04 (2006.01); C07D 405/06 (2006.01); C07D 405/14 (2006.01); C07D 413/10 (2006.01); C07D 413/12 (2006.01); C07D 417/10 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); C07D 471/08 (2006.01); C07D 491/04 (2006.01);
U.S. Cl.
CPC ...
C07D 209/34 (2013.01); A61K 45/06 (2013.01); A61P 25/16 (2018.01); C07D 401/12 (2013.01); C07D 403/04 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/04 (2013.01); C07D 405/06 (2013.01); C07D 405/14 (2013.01); C07D 413/10 (2013.01); C07D 417/10 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 471/08 (2013.01); C07D 491/04 (2013.01); C07D 413/12 (2013.01);
Abstract

The present invention relates to compounds of Formula (I): and pharmaceutically acceptable salts or prodrug thereof. The present invention also relates to compositions comprising at least one compound of Formula (I), and methods of using the compounds of Formula (I) for treatment or prophylaxis of lysosomal storage diseases, neurodegenerative disease, cystic disease, cancer, or a diseases or disorders associated with elevated levels of glucosylceramide (GlcCer), glucosylsphingosine (GlcSph) and/or other glucosylceramide-based glycosphingolipids (GSLs).

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