The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2015
Filed:
Aug. 05, 2011
Vadim Y. Dudkin, Lansdale, PA (US);
Mark E. Fraley, North Wales, PA (US);
Kenneth L. Arrington, Revere, MA (US);
Mark E. Layton, Harleysville, PA (US);
Alexander J. Reif, Holland, PA (US);
Kevin J. Rodzinak, Schwenksville, PA (US);
Joseph E. Pero, Harleysville, PA (US);
Vadim Y. Dudkin, Lansdale, PA (US);
Mark E. Fraley, North Wales, PA (US);
Kenneth L. Arrington, Revere, MA (US);
Mark E. Layton, Harleysville, PA (US);
Alexander J. Reif, Holland, PA (US);
Kevin J. Rodzinak, Schwenksville, PA (US);
Joseph E. Pero, Harleysville, PA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention is directed to benzimidazolone derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved, such as schizophrenia.