This inventor holds 2 USPTO granted patents. Top assignee: Cell Genesys, Inc.. Active years: 1996-2000.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 1996-2000
Title: Mariona Lourdes De Rafael: Innovator in Homologous Recombination
Introduction
Mariona Lourdes De Rafael is a prominent inventor based in Barcelona, Spain. She has made significant contributions to the field of genetic engineering, particularly in the area of homologous recombination. With a total of 2 patents, her work focuses on developing methods that enhance the potential of allogeneic and universal donor cells.
Latest Patents
De Rafael's latest patents include innovative techniques for homologous recombination aimed at inactivating genes associated with MHC antigens. The first patent details a method for inactivating the β2-microglobulin gene to reduce or eliminate the expression of functional Class I MHC antigens. This advancement allows for the creation of allogeneic donor cells that can be utilized in various therapeutic applications. The second patent expands on this concept by targeting both the β2-microglobulin gene and the IFN-γR gene, facilitating the development of universal donor cells. These cells can be modified embryonically to produce chimeric or transgenic mammalian hosts, which may serve as sources for universal donor organs or models for drug and transplantation therapies.
Career Highlights
Mariona De Rafael is currently associated with Cell Genesys, Inc., where she continues to push the boundaries of genetic research. Her work has garnered attention for its potential applications in medicine and transplantation.
Collaborations
Throughout her career, De Rafael has collaborated with notable scientists, including Raju S Kucherlapati and Beverly H Koller. These partnerships have enriched her research and contributed to the advancement of her innovative projects.
Conclusion
Mariona Lourdes De Rafael stands out as a key figure in the field of genetic engineering, with her patents paving the way for future advancements in donor cell technology. Her contributions are vital for the ongoing development of therapies that could revolutionize organ transplantation and genetic research.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile