The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2000
Filed:
May. 18, 1995
Raju Kucherlapati, Darien, CT (US);
Beverly H Koller, Carrboro, NC (US);
Oliver Smithies, Chapel Hill, NC (US);
Robert B Dubridge, Belmont, CA (US);
Gary Greenburg, San Carlos, CA (US);
Daniel J Capon, Hillsborough, CA (US);
Steven R Williams, San Francisco, CA (US);
Mariona Lourdes De Rafael, Barcelona, ES;
Cell Genesys, Inc., Foster City, CA (US);
Abstract
Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. Particularly, the .beta..sub.2- microglobulin gene is inactivated for reducing or eliminating the expression of functional Class I MHC antigens. The resulting cells may be used as allogeneic donor cells. Methods for homologous recombination in non-transformed mammalian somatic cells are also described.