Company Filing History:
Years Active: 1996-2003
Title: Innovations by Gary Greenburg
Introduction
Gary Greenburg is a notable inventor based in San Carlos, CA (US). He has made significant contributions to the field of genetic engineering, particularly in the area of homologous recombination. With a total of 3 patents, his work has the potential to revolutionize organ transplantation and therapeutic models.
Latest Patents
One of Gary Greenburg's latest patents focuses on "Homologous recombination for universal donor cells and chimeric mammalian hosts." This patent describes a method where homologous recombination is employed to inactivate genes associated with MHC antigens. Specifically, the β-microglobulin gene is targeted to reduce or eliminate the expression of functional Class I MHC antigens. The resulting cells can serve as universal donor cells. Additionally, embryonic stem cells can be modified using homologous recombination to create chimeric or transgenic mammalian hosts, which may provide universal donor organs or serve as models for drug and transplantation therapies.
Another significant patent is titled "Homologous recombination for allogeneic donor cells." Similar to the previous patent, this invention utilizes homologous recombination to inactivate genes related to MHC antigens. The β2-microglobulin gene is inactivated to reduce the expression of functional Class I MHC antigens, allowing the resulting cells to function as allogeneic donor cells. Methods for homologous recombination in non-transformed mammalian somatic cells are also detailed in this patent.
Career Highlights
Gary Greenburg is currently associated with Cell Genesys, Inc., where he continues to innovate in the field of genetic research. His work has garnered attention for its potential applications in medicine and biotechnology.
Collaborations
Some of Gary's notable coworkers include Raju S Kucherlapati and Beverly H Koller, who have collaborated with him on various projects and research initiatives.
Conclusion
Gary Greenburg's contributions to genetic engineering through his patents on homologous recombination are paving the way for advancements in organ transplantation and therapeutic models. His innovative work continues to inspire future research in the field.