The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 1996
Filed:
Dec. 30, 1993
Raju Kucherlapati, Darien, CT (US);
Beverly H Koller, Carrboro, NC (US);
Oliver Smithies, Chapel Hill, NC (US);
Robert B Dubridge, Belmont, CA (US);
Gary Greenburg, San Carlos, CA (US);
Daniel J Capon, Hillsborough, CA (US);
Steven R Williams, San Francisco, CA (US);
Mariona L De Rafael, Barcelona, ES;
Cell Genesys, Foster City, CA (US);
Abstract
Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. Particularly, each of the .beta..sub.2- microglobulin gene and the IFN-.gamma.R gene is inactivated for reducing or eliminating the expression of functional MHC antigens. The resulting cells may be used as universal donor cells. In addition, embryonic stem cells may be modified by homologous recombination for use in producing chimeric or transgenic mammalian hosts, which may be used as source of universal donor organs, or as models for drug and transplantation therapies. Methods for homologous recombination in non-transformed mammalian somatic cells are also described.