Beverly H Koller

Title: The Innovative Contributions of Beverly H. Koller

Introduction

Beverly H. Koller is a prominent inventor based in Carrboro, NC (US), known for her significant contributions to the field of genetic engineering. With a total of 5 patents, she has made remarkable advancements in the development of universal donor cells and chimeric mammalian hosts.

Latest Patents

Koller's latest patents focus on the use of homologous recombination to create universal donor cells. One of her notable inventions involves inactivating the β-microglobulin gene to reduce or eliminate the expression of functional Class I MHC antigens. This innovation allows for the creation of cells that can serve as universal donors. Additionally, she has developed methods for modifying embryonic stem cells through homologous recombination, enabling the production of chimeric or transgenic mammalian hosts. These hosts can be utilized as sources of universal donor organs or as models for drug and transplantation therapies. Another patent addresses the use of homologous recombination for allogeneic donor cells, further enhancing the potential for organ transplantation.

Career Highlights

Throughout her career, Beverly H. Koller has worked with esteemed organizations such as Cell Genesys, Inc. and the University of North Carolina at Chapel Hill. Her work has significantly impacted the field of genetic research and therapy.

Collaborations

Koller has collaborated with notable scientists, including Oliver Smithies and Raju S. Kucherlapati, contributing to groundbreaking research in her field.

Conclusion

Beverly H. Koller is a trailblazer in genetic engineering, with her innovative patents paving the way for advancements in organ transplantation and genetic therapies. Her contributions continue to influence the scientific community and improve medical outcomes.