Mahesh Mathrubutham

Title: Mahesh Mathrubutham: Innovator in Nuclear Hormone Receptor Research

Introduction

Mahesh Mathrubutham is a notable inventor based in Cupertino, CA. He has made significant contributions to the field of biochemistry, particularly in the area of nuclear hormone receptor research. His innovative work has led to the development of methods that enhance our understanding of hormone receptor interactions.

Latest Patents

Mahesh holds a patent for "Assays for nuclear hormone receptor binding." This patent involves methods and genetic constructs designed to detect the binding of nuclear hormone receptors to coactivators or corepressors. The techniques utilize enzyme fragment complementation, employing fragments of β-galactosidase as a detection system. The methods involve transforming cells to express a large fragment of β-galactosidase fused to a member of the complex with nuclear hormone receptors, localized in the nucleus. Additionally, cells express a small fragment of β-galactosidase fused to the nuclear hormone receptor, allowing for binding upon stimulation with a ligand. He has 1 patent to his name.

Career Highlights

Mahesh is currently associated with DiscoverX Corporation, where he continues to advance his research in nuclear hormone receptors. His work has implications for understanding various biological processes and potential therapeutic applications.

Collaborations

Some of Mahesh's coworkers include Chin Yee Loh and Thomas S Wehrman, who contribute to the collaborative environment at DiscoverX Corporation.

Conclusion

Mahesh Mathrubutham's innovative research and patent in nuclear hormone receptor binding exemplify his commitment to advancing scientific knowledge. His contributions are valuable to the field and highlight the importance of collaboration in research.