Magnolia Bostick

Title: Magnolia Bostick: Innovator in Nucleic Acid Library Preparation

Introduction

Magnolia Bostick is a prominent inventor based in San Mateo, CA (US). She has made significant contributions to the field of molecular biology, particularly in the preparation of nucleic acid libraries. With a total of 8 patents to her name, Bostick's work has advanced the methodologies used in genetic research and sequencing.

Latest Patents

Bostick's latest patents include innovative methods for preparing nucleic acid libraries. One of her notable inventions involves methods of preparing nucleic acid libraries, which encompass producing various libraries, such as expression libraries and immune cell receptor repertoire libraries, from double-stranded complementary DNA (cDNA). This process utilizes a template-switching reaction involving an RNA sample. Additionally, her methods allow for the preparation of libraries from single cells, as well as libraries indexed at the single-cell level.

Another significant patent focuses on preparing a next-generation sequencing (NGS) library from an RNA sample. This method combines the RNA sample with a first strand cDNA primer and a template switch oligonucleotide under specific synthesis conditions. The resulting product undergoes amplification to produce double-stranded cDNA, which is then tagmented with a transposome. This innovative approach facilitates the creation of NGS libraries, further enhancing the capabilities of genetic sequencing.

Career Highlights

Magnolia Bostick is currently employed at Takara Bio USA, Inc., where she continues to develop groundbreaking technologies in the field of molecular biology. Her work has not only contributed to scientific advancements but has also positioned her as a leading figure in her area of expertise.

Collaborations

Bostick collaborates with esteemed colleagues, including Andrew Alan Farmer and Ian B Oglesby. These partnerships have fostered a collaborative environment that encourages innovation and the sharing of ideas.

Conclusion

Magnolia Bostick's contributions to the field of nucleic acid library preparation are invaluable. Her innovative methods and patents have significantly impacted genetic research, making her a noteworthy inventor in the scientific community.