Company Filing History:
Years Active: 2005-2019
Title: Lonnie O'Neal Ingram: Innovator in Biocatalysis
Introduction
Lonnie O'Neal Ingram is a prominent inventor based in Gainesville, FL (US). He has made significant contributions to the field of biocatalysis, holding a total of 16 patents. His work focuses on the efficient production of succinic acid and other valuable products from renewable biological feedstocks.
Latest Patents
One of Ingram's latest patents is titled "Engineering the pathway for succinate production." This invention relates to biocatalysts that enable the efficient production of succinic acid from carbohydrate feedstocks. The biocatalysts exhibit high efficiency for growth-coupled production, achieved through genetic manipulation and metabolic evolution. Specifically, these biocatalysts can produce succinic acid at high titers and yields in mineral salts media during pH-controlled batch fermentation without the need for exogenous genetic material. The genetic modifications focus on energy-conserving strategies and the elimination of alternative NADH oxidation routes, enhancing succinic acid production efficiency.
Another notable patent is "Variants of glycerol dehydrogenase having D-lactate dehydrogenase activity and uses thereof." This invention provides methods for designing and generating glycerol dehydrogenase (GlyDH) variants with altered functions compared to the parent polypeptide. It also includes nucleic acids encoding these GlyDH variants and methods for producing lactic acids using host cells that comprise the polynucleotides.
Career Highlights
Lonnie O'Neal Ingram is affiliated with the University of Florida Research Foundation, Incorporated. His innovative work has positioned him as a leader in the field of biocatalysis, contributing to advancements in sustainable production methods.
Collaborations
Ingram has collaborated with notable colleagues, including Keelnatham T Shanmugam and Shengde Zhou. These partnerships have further enhanced the impact of his research and inventions.
Conclusion
Lonnie O'Neal Ingram's contributions to biocatalysis and renewable resource utilization are noteworthy. His innovative patents reflect a commitment to advancing sustainable production methods in the field.
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