Longlong Si

Title: **Innovations by Longlong Si: Pioneering Advances in Viral Research**

Introduction

Longlong Si, an innovative inventor based in Beijing, China, has made significant contributions to the field of virology through his inventive work. With a total of two patents, Si focuses on the development of mutated viruses and adeno-associated viruses, advancing our understanding and applications of viral genetics.

Latest Patents

One of Longlong Si's most notable patents is titled "Mutant virus, preparation method therefor and application thereof." This invention relates to a mutated virus, specifically an influenza virus of human or animal origin. The patent outlines a method for preparing this mutated virus by introducing UAG codons into positions upstream of the stop codons in one or more genes of a viral genome using reverse genetic techniques. The mutated virus has potential applications as a live attenuated vaccine and in the creation of controllable and safe virus models.

Another significant patent is for an "Adeno-associated virus with site-directed mutagenesis and site-directed modification and preparation method and application thereof." This patent presents an adeno-associated virus modified through genetic code expansion techniques to incorporate non-natural amino acids into the capsid protein VP1 or its fragments. This innovation allows for the virus to maintain wild-type characteristics while also functioning as a versatile tool for genetic therapy, including the ability to carry functional genes and couple with other molecules.

Career Highlights

Currently affiliated with Peking University, Longlong Si has established himself as a key figure in the research and development of viral technologies. His work has potential implications not only for vaccine development but also for targeted genetic therapy, showcasing the diverse applications of his inventions.

Collaborations

Throughout his career, Longlong Si has collaborated with notable peers, including Demin Zhou and Chuanling Zhang. Together, they contribute to advancing research in virology and genetic engineering, highlighting the importance of teamwork in scientific innovation.

Conclusion

Longlong Si exemplifies the spirit of innovation and dedication to scientific inquiry. His patents are a testament to his expertise and the potential of his work to transform viral research and therapeutic approaches. As the field continues to evolve, inventors like Si pave the way for new solutions to complex challenges in healthcare and disease prevention.