The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 29, 2022

Filed:

Aug. 02, 2016
Applicant:

Peking University, Beijing, CN;

Inventors:

Demin Zhou, Beijing, CN;

Longlong Si, Beijing, CN;

Xueying Zhou, Beijing, CN;

Ziwei Zhang, Beijing, CN;

Huan Xu, Beijing, CN;

Zhenyu Tian, Beijing, CN;

Chuanling Zhang, Beijing, CN;

Sulong Xiao, Beijing, CN;

Qing Xia, Beijing, CN;

Lihe Zhang, Beijing, CN;

Assignee:

PEKING UNIVERSITY, Beijing, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/145 (2006.01); C12N 7/00 (2006.01); A61K 39/12 (2006.01); A61K 35/76 (2015.01); C12N 9/00 (2006.01); C12N 15/63 (2006.01);
U.S. Cl.
CPC ...
A61K 39/12 (2013.01); A61K 35/76 (2013.01); C12N 7/00 (2013.01); C12N 9/93 (2013.01); C12N 15/63 (2013.01); C12N 2760/16021 (2013.01); C12N 2760/16022 (2013.01); C12N 2760/16034 (2013.01); C12N 2760/16134 (2013.01); C12N 2760/16162 (2013.01); C12Y 601/01026 (2013.01);
Abstract

The present invention relates to a mutated virus. Said virus can be an influenza virus of human or other animal origin. The present invention also relates to a method for preparing the mutated virus, the method comprising introducing UAG codons into positions upstream of the stop codons per se of one or more genes of a viral genome by reverse genetic techniques. The present invention further relates to uses of the mutated virus, for example, as a live attenuated vaccine, or in replication of controllable and safe virus models, and the like.


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