Lixin Chen

Title: Innovations and Contributions of Inventor Lixin Chen

Introduction

Lixin Chen is a notable inventor based in Beverly, MA (US), recognized for his significant contributions to the field of molecular biology. With a total of four patents to his name, Chen has made strides in the understanding and manipulation of nucleic acids.

Latest Patents

One of Lixin Chen's latest patents focuses on "Mapping the location, type and strand of damaged and/or mismatched nucleotides in double-stranded DNA." This method involves incubating a double-stranded nucleic acid with a nick, utilizing a ligase and a nucleotide mix that includes modified nucleotides. The result is a product that contains a newly synthesized strand of duplex nucleic acid, which can be used to map damaged nucleoside monophosphates. Another significant patent is titled "Repair of nucleic acids for improved amplification." This invention provides methods and compositions for repairing polynucleotides to enhance their fidelity and yield during amplification reactions. The process involves a reaction mixture that includes a ligase and a cofactor, allowing for effective repair without the need for time-sensitive incubation.

Career Highlights

Lixin Chen has worked with reputable organizations, including New England Biolabs, Inc. His experience in these companies has contributed to his expertise in the field of biotechnology and molecular research.

Collaborations

Throughout his career, Lixin Chen has collaborated with esteemed colleagues such as Thomas C Evans, Jr. and Barton E Slatko. These partnerships have likely enriched his research and innovation endeavors.

Conclusion

Lixin Chen's work in the field of molecular biology, particularly in the repair and mapping of nucleic acids, showcases his innovative spirit and dedication to advancing scientific knowledge. His contributions continue to impact the field positively.