Linjiang Tong

Title: Linjiang Tong: Innovator in Pharmaceutical Compounds

Introduction

Linjiang Tong is a prominent inventor based in Shanghai, China. He has made significant contributions to the field of pharmaceutical compounds, particularly in the development of selective inhibitors for various diseases. With a total of 2 patents, his work showcases innovative approaches to drug development.

Latest Patents

Linjiang Tong's latest patents include the following:

1. **Pyrimido[5,4-b]pyrrolizin compound, optical isomer thereof, preparation method therefor and use thereof** - This invention relates to a pyrimido[5,4-b]pyrrolizin compound represented by general formula I. The compound exhibits good inhibitory activity on the kinase BTK at both the molecular and cellular levels. Additionally, it demonstrates promising anti-tumor activity and favorable pharmacokinetic properties in vivo.

2. **Pyrimido[5,4-B]indolizine or pyrimido[5,4-B]pyrrolizine compound, preparation method and use thereof** - This disclosure pertains to a pyrimido[5,4-b]indolizine or pyrimido[5,4-b]pyrrolizine compound. The compounds show good inhibitory activities against BTK at both molecular and cellular levels. Notably, they exhibit low activity against Ramos cells of normal human B lymphoma cells while maintaining high activity against BTK-sensitive human diffuse large B lymphoma TMD8 cells. This indicates that these compounds are highly selective with minimal off-target effects.

Career Highlights

Linjiang Tong has worked at several prestigious institutions, including the Shanghai Institute of Materia Medica and the Chinese Academy of Sciences. His research has focused on developing innovative compounds that can effectively target specific kinases involved in various diseases.

Collaborations

Throughout his career, Linjiang Tong has collaborated with notable colleagues, including Ao Zhang and Jian Ding. These collaborations have contributed to the advancement of his research and the successful development of his patented compounds.

Conclusion

Linjiang Tong is a distinguished inventor whose work in pharmaceutical compounds has the potential to significantly impact the field of medicine. His innovative patents reflect a commitment to developing selective inhibitors that can lead to effective treatments for various diseases.