The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2025
Filed:
Apr. 24, 2020
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, CN;
Ao Zhang, Shanghai, CN;
Jian Ding, Shanghai, CN;
Hua Xie, Shanghai, CN;
Zilan Song, Shanghai, CN;
Yu Xue, Shanghai, CN;
Li Xing, Shanghai, CN;
Linjiang Tong, Shanghai, CN;
Meiyu Geng, Shanghai, CN;
Abstract
The present invention relates to a pyrimido[5,4-b]pyrrolizin compound represented by general formula I, an optical isomer thereof, a preparation method therefor, a pharmaceutical composition containing same, and a use thereof. The compound according to the present invention has good inhibitory activity on the kinase BTK at both the molecular level and the cellular level. Meanwhile, the compound also has good anti-tumor activity and pharmacokinetic properties in vivo.