Company Filing History:
4 out of 3,107 
1 out of 1 Years Active: 2018-2025
Title: Innovations by Inventor Hua Xie in Shanghai, CN
Introduction
Hua Xie, a prominent inventor based in Shanghai, China, has made significant contributions to the field of pharmacology through his innovative work. With a total of 4 patents to his name, his research focuses on compounds that exhibit substantial therapeutic potential, particularly in the fight against cancer.
Latest Patents
Hua Xie's latest patents include the development of a Pyrimido[5,4-b]pyrrolizin compound, along with its optical isomer. This invention presents a preparation method and outlines its use, particularly highlighting the compound's strong inhibitory activity on the kinase BTK at both molecular and cellular levels. Jiang Ding and Meiyu Geng have collaborated with him in these endeavors, with the latter being a significant female contributor in his team.
Another important patent involves the Pyrimido[5,4-b]indolizine or Pyrimido[5,4-b]pyrrolizine compound, emphasizing its preparation method and efficacy. The compounds not only showcase high selectivity against BTK-sensitive human diffuse large B lymphoma cells, but also demonstrate low activity against normal B lymphoma cells, reducing potential side effects.
Career Highlights
Hua Xie's career includes notable roles at esteemed institutions such as the Chinese Academy of Sciences and the Shanghai Institute of Materia Medica. His work has been instrumental in advancing research in medicinal chemistry and drug development.
Collaborations
Throughout his career, Hua has collaborated with various esteemed professionals, including Jian Ding and Meiyu Geng. Their joint research efforts have enabled significant advancements in the understanding of kinase inhibitors and their applications in targeted cancer therapies.
Conclusion
Hua Xie embodies the spirit of innovation in the field of pharmaceutical sciences. His work not only contributes to the existing body of knowledge but also offers hopeful prospects for more effective cancer treatments through his patented inventions. As research and development continue, his endeavors promise to yield impactful therapeutic solutions in the near future.