The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2018
Filed:
Feb. 15, 2015
Applicant:
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, CN;
Inventors:
Wenhu Duan, Shanghai, CN;
Jian Ding, Shanghai, CN;
Yongcong Lv, Shanghai, CN;
Hua Xie, Shanghai, CN;
Assignee:
Primary Examiner:
Int. Cl.
CPC ...
C07D 231/56 (2006.01); C07D 261/20 (2006.01); C07D 413/12 (2006.01); C07D 401/12 (2006.01); C07D 491/048 (2006.01); C07D 495/04 (2006.01);
U.S. Cl.
CPC ...
C07D 231/56 (2013.01); C07D 261/20 (2013.01); C07D 401/12 (2013.01); C07D 413/12 (2013.01); C07D 491/048 (2013.01); C07D 495/04 (2013.01);
Abstract
The present invention relates to a naphthylamide compound of the structure as represented by formula (I), medicinal salts, prodrugs and hydrates or solvates thereof, and also relates to a method of preparing the compounds, pharmaceutical compositions comprising the compounds and the uses thereof as protein tyrosine kinase inhibitors, particularly as VEGFR-2 inhibitors, in preparing drugs for preventing and treating diseases related to abnormal angiogenesis.