The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2020
Filed:
Nov. 24, 2017
Pyrimido[5,4-b]indolizine or pyrimido[5,4-b]pyrrolizine compound, preparation method and use thereof
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, CN;
Ao Zhang, Shanghai, CN;
Jian Ding, Shanghai, CN;
Hua Xie, Shanghai, CN;
Zilan Song, Shanghai, CN;
Yu Xue, Shanghai, CN;
Linjiang Tong, Shanghai, CN;
Meiyu Geng, Shanghai, CN;
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACAD, Shanghai, CN;
Abstract
The present disclosure relates to a Pyrimido[5,4-b]indolizine or pyrimido[5,4-b]pyrrolizine compound, preparation method thereof and use thereof. The compounds of the present invention have good inhibitory activities against BTK at the molecular and cellular levels. Importantly, the compounds of the present invention have low activity against Ramos cells of normal human B lymphoma cells, and have high activity against BTK-sensitive human diffuse large B lymphoma TMD8 cells, indicating that these type of compounds with novel structural are highly selective, off-target phenomenon and corresponding side effects are low. Thus it is a selective inhibitor of BTK with development potential.