Location History:
- Wilmington, DE (US) (2010)
- Newark, DE (US) (2010)
Company Filing History:
Years Active: 2010
Title: Innovations by Linda Jane DeCarolis: Pioneering Advances in Peptide Technology
Introduction
Linda Jane DeCarolis is a prominent inventor based in Wilmington, DE, who has made significant contributions to the field of biochemistry. With a remarkable portfolio of seven patents, her work primarily focuses on developing acid-resistant peptide tags that enhance the production and purification of bioactive peptides.
Latest Patents
Her latest patents include the "Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate." This innovation provides an effective solubility tag, facilitating the production of peptides in insoluble forms. The engineered inclusion body tag is specifically designed for improved resistance to acid hydrolysis, allowing for cleaner separation of the desired peptide during processing. Another notable patent pertains to "Solubility tags for the expression and purification of bioactive peptides," which outlines methods for generating insoluble fusion peptides that can be isolated after cleavage from inclusion body tags.
Career Highlights
Linda works at E.I. du Pont de Nemours and Company, a leading science and technology company focused on several innovative disciplines. Throughout her career, she has focused on the intersection of technology and biology, continually striving to enhance techniques for peptide purification and expression.
Collaborations
In her professional journey, Linda has collaborated with other distinguished scientists, including Stephen R. Fahnestock and Hong Peng Wang. These collaborations have enriched her research and development efforts, allowing her to push the boundaries of current methodologies and introduce groundbreaking solutions in peptide technology.
Conclusion
Linda Jane DeCarolis stands out as a trailblazer in her field, demonstrating the power of innovation in the biotechnology sector. Her patents not only showcase her creativity and technical skills but also contribute significantly to advancements in peptide research, benefiting academia and industry alike. Through her efforts, she continues to inspire future generations of scientists and inventors.