Lawrence Stern

Title: The Innovations of Lawrence Stern

Introduction

Lawrence Stern is a notable inventor based in Duarte, CA (US). He has made significant contributions to the field of cancer treatment through his innovative work on chimeric antigen receptors. With a total of 2 patents, his inventions focus on targeted therapies for malignancies expressing specific tumor antigens.

Latest Patents

Stern's latest patents include "Targeted chimeric antigen receptor modified T cells for treatment of IL13Rα2 positive malignancies" and "Chimeric antigen receptors and methods for reducing toxicity." The first patent describes chimeric antigen receptor molecules that incorporate a variant IL-13, which demonstrates a more selective binding to IL13Rα2 compared to IL13Rα1. This selectivity allows for more effective treatment of IL13Rα2 expressing cancers. The second patent outlines nucleic acid molecules that encode a chimeric antigen receptor and a protease-sensitive scFv, designed to target tumor antigens while minimizing toxicity.

Career Highlights

Throughout his career, Lawrence Stern has worked with esteemed institutions such as City of Hope and Leland Stanford Junior University. His research has significantly advanced the understanding and treatment of cancer, particularly through the development of innovative therapeutic strategies.

Collaborations

Stern has collaborated with notable colleagues, including Christine E. Brown and Xiuli Wang. These partnerships have contributed to the success and impact of his research in the field of cancer immunotherapy.

Conclusion

Lawrence Stern's contributions to the field of cancer treatment through his innovative patents highlight his role as a leading inventor. His work continues to pave the way for advancements in targeted therapies, offering hope for patients with specific malignancies.