The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2023
Filed:
Jan. 25, 2019
Applicant:
City of Hope, Duarte, CA (US);
Inventors:
Xiuli Wang, Temple City, CA (US);
Stephen J. Forman, Duarte, CA (US);
Lawrence Stern, Duarte, CA (US);
Christine E. Brown, Duarte, CA (US);
Joseph Cohen, Duarte, CA (US);
Assignee:
City of Hope, Duarte, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); A61K 35/17 (2015.01); C07K 16/18 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 38/177 (2013.01); A61K 35/17 (2013.01); C07K 16/18 (2013.01); C12N 15/86 (2013.01); C07K 2317/622 (2013.01);
Abstract
Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3ζ signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.