City of Hope

Leland Stanford Junior University

Lawrence Stern

Christine E Brown

Stephen J Forman

Ignacio Moraga Gonzalez

Xiuli Wang

K Christopher Garcia

Joseph Cohen

Xin Yang

Chimeric antigen receptor molecules that include a variant IL-13. The variant IL-13 are more selective for IL13Rα2 than IL13Rα1 by virtue of weaker binding to IL13Rα1. The chimeric antigen receptors can be used to treat IL13Rα2 expressing cancers.

Targeted chimeric antigen receptor modified T cells for treatment of IL13Rα2 positive malignancies

Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3&#x3b6; signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.

Chimeric antigen receptors and methods for reducing toxicity

Growing community of inventors

Duarte, CA, United States of America

Lawrence Stern