This inventor holds 3 USPTO granted patents and 1 published patent application, plus 1 CIPO patent and 3 EPO patents. Top assignee: Merck Patent Gmbh. Active years: 2018-2020.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Location History:
- Darmstadt, DE (2018)
- Frankfurt-am-Main, DE (2019 - 2020)
Company Filing History:
Years Active: 2018-2020
Title: Laura Rhiel: Innovating Protein Display and Antibody Engineering
Introduction
Laura Rhiel is a notable inventor based in Frankfurt am Main, Germany. With a robust portfolio of three patents, she has made significant contributions to the field of biochemistry, particularly in protein display methods and antibody engineering.
Latest Patents
Two of Laura's latest patents demonstrate her innovative approach to protein engineering. The first patent, titled "Methods for non-covalent Fc-domain-containing protein display on the surface of cells and methods of screening thereof," provides methods for the non-covalent surface display of proteins of interest (POI), especially Fc-domain containing proteins like antibodies. This invention not only enhances the ability to screen and select proteins of a desired phenotype but also introduces polynucleotides and proteins that facilitate these groundbreaking methods.
Her second patent, "Anti-TNFα antibodies with pH-dependent antigen binding for improved target clearance," focuses on engineering anti-TNFα antibodies to exhibit pH-sensitive antigen binding. This technology specifically targets adalimumab (Humira®) and its biologically active variants, modifying the amino acid sequence in the variable regions to enhance functionality. The innovative modifications of the CDR domains, by replacing amino acid residues with histidine residues, are pivotal in improving the therapeutic efficacy of these antibodies.
Career Highlights
Laura currently works at Merck Patent GmbH, where she not only contributes to her research but also influences pharmaceutical advancements in the industry. Her expertise and pioneering work have positioned her as a significant figure in the world of protein engineering and biotechnology.
Collaborations
Throughout her career, Laura has collaborated with other accomplished professionals, including colleagues Stefan Becker and Bjoern Hock. These joint efforts have fostered an environment of creativity and innovation, enabling the development of cutting-edge technologies in their field.
Conclusion
In conclusion, Laura Rhiel's inventive spirit and dedication to advancing biochemical research are evident through her impactful patents and collaborations. As she continues her work at Merck Patent GmbH, the scientific community eagerly anticipates further innovations from this remarkable inventor.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile