The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2018
Filed:
Dec. 11, 2013
Applicant:
Merck Patent Gmbh, Darmstadt, DE;
Inventors:
Ralph Guenther, Griesheim, DE;
Bjoern Hock, Maintal-Doernigheim, DE;
Stefan Becker, Darmstadt, DE;
Laura Rhiel, Darmstadt, DE;
Assignee:
MERCK PATENT GmbH, Darmstadt, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/10 (2006.01); C07K 16/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1037 (2013.01); C07K 16/005 (2013.01); C07K 2317/14 (2013.01); C07K 2317/569 (2013.01); C07K 2317/624 (2013.01);
Abstract
The invention relates to a method for the production and non-covalent surface display of antibodies and derived fragments as well as molecule libraries based thereon on the surface ofcells. The non-covalent manner of the surface display renders possible the selection of specific variants by means of high throughput screening and the subsequent switchable secretion of the selected binding molecule into the culture supernatant for biochemical characterization.