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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10676733 B1

PDFFull Text
Expired
Date of Patent:
Jun. 09, 2020

Filed:

Oct. 27, 2015

Methods for non-covalent fc-domain-containing protein display on the surface of cells and methods of screening thereof

Applicant:

Merck Patent Gmbh, Darmstadt, DE;

Inventors:

Laura Rhiel, Frankfurt am Main, DE;

Stefan Becker, Darmstadt, DE;

Ralf Guenther, Griesheim, DE;

Bjoern Hock, Maintal, DE;

Daniel Helman, Qiryat Ono, IL;

Mira Toister-Achituv, Rehovot, IL;

Simon Krah, Darmstadt, DE;

Assignee:

Merck Patent GmbH, Darmstadt, DE;

Attorney:

Womble Bond Dickinson (US) LLP

Primary Examiner:

Christian C Boesen

Int. Cl.
CPC ...
C40B 30/06 (2006.01); C12N 15/10 (2006.01); C07K 14/36 (2006.01); C07K 14/315 (2006.01); C07K 14/195 (2006.01); C07K 16/00 (2006.01); C12N 15/81 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1037 (2013.01); C07K 14/195 (2013.01); C07K 14/315 (2013.01); C07K 14/36 (2013.01); C07K 16/005 (2013.01); C12N 15/1075 (2013.01); C12N 15/81 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/22 (2013.01); C07K 2319/70 (2013.01); C40B 30/06 (2013.01);
Abstract

The present invention provides methods for the non-covalent surface display of proteins of interest (POI), in particular for Fc-domain containing proteins such as antibodies. The inventive method may be used to screen and select proteins of interest of a desired phenotype. The present invention further discloses polynucleotides and proteins and methods of producing the same, which may be used in carrying out the inventive method.

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Rhiel, Laura. (2020). Methods for non-covalent fc-domain-containing protein display on the surface of cells and methods of screening thereof (U.S. Patent No. 10676733). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10676733

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