This inventor holds 2 USPTO granted patents and 5 published patent applications. Top assignee: Cold Spring Harbor Laboratory. Active years: 2010-2012.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Location History:
- Cold Spring Harbor, NY (US) (2010)
- Hannover, DE (2012)
Company Filing History:
Years Active: 2010-2012
Title: Lars Zender: Innovator in Liver Cancer Research
Introduction
Lars Zender is a prominent inventor based in Hannover, Germany. He has made significant contributions to the field of liver cancer research, holding 2 patents that focus on innovative methods for understanding and treating this devastating disease.
Latest Patents
Zender's latest patents include "Orthotopic and genetically tractable non-human animal model for liver cancer and the uses thereof." This invention provides a genetically tractable in situ non-human animal model for hepatocellular carcinoma. The model is useful in understanding the molecular mechanisms of liver cancer, the genetic alterations that lead to chemoresistance or poor prognosis, and in identifying and evaluating new therapies against hepatocellular carcinomas. The liver cancer model is created by altering hepatocytes to increase oncogene expression, reduce tumor suppressor gene expression, or both, and by transplanting the resulting hepatocytes into a recipient non-human animal. Additionally, this invention relates to the use of RNA interference (RNAi) technology in vivo to efficiently identify genes associated with liver cancer, particularly those encoding tumor suppressors, by knocking out candidate genes using RNAi and observing whether tumors develop.
Another significant patent is "Role of FGF-20 in cancer diagnosis and treatment." This invention provides methods for diagnosing cancers in humans by detecting DNA amplifications in chromosomal region 8p22, which encompasses the FGF-20 gene and the EFHA2 gene. It also includes cancer treatment methods using inhibitors of FGF-20 and EFHA2. Furthermore, the invention provides methods for promoting successful regeneration of liver function, which can be therapeutically used to improve liver function following transplantation in both recipient and donor subjects.
Career Highlights
Lars Zender is affiliated with Cold Spring Harbor Laboratory, where he continues to advance research in cancer biology. His work has been instrumental in developing new models and methods that enhance our understanding of liver cancer.
Collaborations
Zender has collaborated with notable researchers in the field, including Scott William Lowe and Mona S Spector. These collaborations have further enriched his research and contributed to the advancement of cancer treatment methodologies.
Conclusion
Lars Zender's innovative work in liver cancer research exemplifies the critical role of inventors in advancing medical science. His patents not only provide valuable insights into cancer mechanisms but also pave the way for
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile