Location History:
- San Francisco, CA (US) (2022)
- Palo Alto, CA (US) (2021 - 2024)
Company Filing History:
6 out of 5,309 
2 out of 1,373 
2 out of 517 
Years Active: 2021-2025
Title: The Innovative Contributions of Lars Steinmetz
Introduction
Lars Steinmetz is a prominent inventor based in San Francisco, CA, known for his significant contributions to the field of genetic engineering. With a total of five patents to his name, Steinmetz has made remarkable advancements in the multiplex production and phenotyping of genetically engineered cells.
Latest Patents
One of his latest patents focuses on the multiplex production and barcoding of genetically engineered cells. This innovation relates to high-throughput multiplex genome editing, utilizing RNA-guided nucleases and genomic barcoding. The system facilitates precise genome editing at desired target chromosomal loci through homology directed repair. By integrating guide RNA and donor DNA sequences as a genomic barcode, it allows for the identification, isolation, and massively-parallel validation of individual variants from a pool of transformants. Additionally, he has developed methods for editing codons outside of canonical guide RNA recognition regions, enabling complete saturation mutagenesis of protein-coding genes.
Another significant patent addresses methods of treatment, genetic screening, and disease models for heart conditions associated with RBM20 deficiency. This includes methods for treating heart conditions such as RBM20-dependent dilated cardiomyopathy and heart failure. The patent outlines the use of compounds that upregulate the expression of RBM20, such as all-trans retinoic acid. Furthermore, it provides methods for genetic screening to detect the presence of a P633L mutation in RBM20, identifying individuals with a genetic predisposition to developing RBM20-dependent DCM.
Career Highlights
Steinmetz has worked with esteemed institutions, including Leland Stanford Junior University and The Brigham and Women's Hospital, Inc. His work has significantly impacted the field of genetic research and treatment methodologies.
Collaborations
Throughout his career, Steinmetz has collaborated with notable professionals, including Utkan Demirci and Ronald W. Davis. These collaborations have further enhanced the scope and impact of his research.
Conclusion
Lars Steinmetz's innovative work in genetic engineering and his contributions to the understanding and treatment of heart conditions highlight his importance in the field. His patents reflect a commitment to advancing medical science and improving patient outcomes.