The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 20, 2024

Filed:

Feb. 08, 2021
Applicants:

The Brigham and Women's Hospital, Inc., Boston, MA (US);

Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Beth Israel Deaconess Medical Center, Boston, MA (US);

Inventors:

Utkan Demirci, Stanford, CA (US);

Ionita Ghiran, Boston, MA (US);

Savas Tasoglu, Storrs, CT (US);

Ronald W. Davis, Palo Alto, CA (US);

Lars Steinmetz, Palo Alto, CA (US);

Naside Gozde Durmus, Palo Alto, CA (US);

Huseyin Cumhur Tekin, Palo Alto, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 13/00 (2006.01); B01L 3/00 (2006.01); B03C 1/32 (2006.01); C12Q 1/18 (2006.01); G01N 15/06 (2006.01); G01N 15/1031 (2024.01); G01N 27/76 (2006.01); G01N 33/487 (2006.01); G01N 33/49 (2006.01); G01N 33/574 (2006.01); G01N 33/80 (2006.01); G01N 15/00 (2006.01); G01N 15/10 (2006.01);
U.S. Cl.
CPC ...
G01N 33/80 (2013.01); B01L 3/502715 (2013.01); B01L 3/502761 (2013.01); B03C 1/32 (2013.01); C12N 13/00 (2013.01); C12Q 1/18 (2013.01); G01N 15/0656 (2013.01); G01N 15/1031 (2013.01); G01N 27/76 (2013.01); G01N 33/487 (2013.01); G01N 33/491 (2013.01); G01N 33/574 (2013.01); B01L 2200/0647 (2013.01); B01L 2300/0654 (2013.01); B01L 2300/0838 (2013.01); B01L 2300/168 (2013.01); B03C 2201/18 (2013.01); B03C 2201/26 (2013.01); G01N 2015/0053 (2013.01); G01N 2015/1006 (2013.01); G01N 2500/10 (2013.01); G01N 2800/042 (2013.01); G01N 2800/26 (2013.01); G01N 2800/52 (2013.01); G01N 2800/7042 (2013.01);
Abstract

Magnetic cell levitation and cell monitoring systems and methods are disclosed. A method for separating a heterogeneous population of cells is performed by placing a microcapillary channel containing the heterogeneous population of cells in a magnetically-responsive medium in the disclosed levitation system and separating the cells by balancing magnetic and corrected gravitational forces on the individual cells. A levitation system is also disclosed, having a microscope on which the microcapillary channel is placed and a set of two magnets between which the microcapillary channel is placed. Additionally, a method for monitoring cellular processes in real-time using the levitation system is disclosed.


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