Larry J Smith

Title: Larry J Smith: Innovator in Gene Expression Modulation

Introduction

Larry J Smith is a prominent inventor based in Omaha, NE (US), known for his significant contributions to the field of gene expression modulation. With a total of 13 patents to his name, Smith has made remarkable advancements in the development of oligonucleotide-based drugs.

Latest Patents

Among his latest patents, Smith has developed methods and compositions for modulating gene expression using oligonucleotide-based drugs administered in vivo or in vitro. His work includes compositions and methods for down-modulating target gene expression through RNA interference. The innovative method involves administering a first oligonucleotide strand to a cell and incubating the cells for a suitable time period for uptake before administering a second oligonucleotide strand. This process results in the formation of an intracellular duplex that effectively catalyzes the degradation of target gene mRNA or inhibits its translation.

Career Highlights

Throughout his career, Larry J Smith has worked with various institutions, including the University of Nebraska. His research has focused on the intricate mechanisms of gene expression and the potential therapeutic applications of oligonucleotide-based drugs.

Collaborations

Smith has collaborated with notable individuals in his field, including Sudhir Paul and Gennady Gololobov. These collaborations have further enriched his research and contributed to the advancement of gene modulation technologies.

Conclusion

Larry J Smith's innovative work in gene expression modulation has positioned him as a key figure in the field. His contributions continue to influence research and development in biotechnology and medicine.