L Mary Smith

Title: L Mary Smith: Innovator in Immunology

Introduction

L Mary Smith is a prominent inventor based in Hillsborough, NC (US), known for her significant contributions to the field of immunology. With a total of 7 patents to her name, she has made remarkable strides in developing methods to enhance immune responses, particularly in cancer treatment.

Latest Patents

Among her latest patents, Smith has developed innovative methods for inducing or enhancing an immune response by administering agonistic glucocorticoid-induced TNFR-family-related receptor (GITR) antibodies. This invention provides binding molecules that specifically target GITR on T cells and dendritic cells. These binding molecules are characterized by their high affinity for human GITR (hGITR) in the presence of a stimulating agent, such as CD3. They are agonistic and effectively abrogate the suppression of Teff cells by Treg cells. The invention encompasses various aspects, including binding molecules, pharmaceutical compositions, nucleic acids, recombinant expression vectors, and host cells for producing these binding molecules. Additionally, methods for using these binding molecules to detect human GITR or modulate its activity, both in vitro and in vivo, are also included.

Career Highlights

Throughout her career, L Mary Smith has worked with notable companies such as Gitr, Inc. and Tolerrx, Inc. Her work has significantly impacted the development of therapies aimed at enhancing immune responses, particularly in oncology.

Collaborations

Smith has collaborated with esteemed colleagues, including Paul D Ponath and Michael Rosenzweig, contributing to the advancement of immunological research and therapeutic innovations.

Conclusion

L Mary Smith's innovative work in immunology, particularly her patents related to GITR antibodies, showcases her dedication to enhancing immune responses in cancer treatment. Her contributions continue to influence the field and pave the way for future advancements.