Gitr, Inc.

Merck Sharp + Dohme Corp.

Tolerrx, Inc.

L Mary Smith

Paul D Ponath

Michael Rosenzweig

Jose F Ponte

Grazyna Szymanska

Patricia Rao

The present invention provides binding molecules that specifically bind to GITR, e.g., human GITR (hGITR), on T cells and dendritic cells. Binding molecules of the invention are characterized by binding to hGITR with high affinity, in the presence of a stimulating agent, e.g., CD3, are agonistic, and abrogate the suppression of Teff cells by Treg cells. Various aspects of the invention relate to binding molecules, and pharmaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such binding molecules. Methods of using a binding molecule of the invention to detect human GITR or to modulate human GITR activity, either in vitro or in vivo, are also encompassed by the invention.

Methods for inducing or enhancing an immune response by administering agonistic glucocorticoid-induced TNFR-family-related receptor (GITR) antibodies

Methods of inducing or enhancing an immune response in a subject having cancer by administering GITR antibodies

GITR antibodies and methods of inducing or enhancing an immune response

Methods of inducing or enhancing an immune response in a subject by administering agonistic GITR binding antibodies

The present invention provides binding molecules that specifically bind to ILT3, e.g., human ILT3 (hILT3), on antigen presenting cells, such as for example, monocytes, macrophages and dendritic cells (DC), e.g., monocyte-derived dendritic cells (MDDC). Various aspects of the invention relate to binding molecules, and pharmaceutical compositions thereof. Methods of using the binding molecules of the invention to detect human ILT3 or to modulate human ILT3 activity, either in vitro or in vivo, are also encompassed by the invention.

ILT3 binding molecules and uses therefor

Methods for inducing or enhancing an immune response by administering agonistic GITR-binding antibodies

GITR-binding antibodies

Growing community of inventors

Hillsborough, NC, United States of America

L Mary Smith