Location History:
- Palo Alto, CA (US) (1993)
- Menlo Park, CA (US) (1990 - 1994)
Company Filing History:
Years Active: 1990-1994
Title: L Bernard Lerch: Innovator in Autoimmunity Treatment
Introduction
L Bernard Lerch is a notable inventor based in Menlo Park, CA (US). He has made significant contributions to the field of immunology, particularly in the treatment of autoimmune diseases. With a total of 6 patents to his name, Lerch's work focuses on innovative therapeutic agents that target specific immune responses.
Latest Patents
Lerch's latest patents include groundbreaking inventions such as "MHC-mediated toxic conjugates useful in ameliorating autoimmunity." This invention outlines methods and materials that are effective in treating autoimmune diseases. The therapeutic agents described are of the formula X--MHC--peptide or MHC--peptide--X, where X represents a functional moiety selected from a toxin and a labeling group. The MHC component is an effective portion of the MHC glycoprotein, which is dissociated from the cell surface. The peptide represents an antigenic sequence associated with an autoantigen. These complexes are designed to target helper T-cells that are specifically immunoreactive with autoantigens.
Another significant patent is "MHC conjugates useful in ameliorating autoimmunity." This invention focuses on complexes that consist essentially of an isolated MHC component and an autoantigenic peptide associated with the antigen binding site of the MHC component. These complexes are also aimed at treating autoimmune diseases effectively.
Career Highlights
Throughout his career, Lerch has worked with various companies, including Anergen, Inc. and Applied Immunesciences, Inc. His work in these organizations has contributed to advancements in immunological research and therapeutic development.
Collaborations
Lerch has collaborated with notable professionals in the field, including Brian R Clark and Somesh D Sharma. These collaborations have further enhanced the impact of his research and innovations.
Conclusion
L Bernard Lerch is a prominent inventor whose work in the field of autoimmunity has led to significant advancements in treatment methodologies. His innovative patents and collaborations continue to influence the landscape of immunological research.