The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 1993
Filed:
Jun. 21, 1989
Somesh D Sharma, Los Altos, CA (US);
L Bernard Lerch, Menlo Park, CA (US);
Brian R Clark, Redwood City, CA (US);
Anergen, Inc., Redwood City, CA (US);
Abstract
The invention is directed to methods and materials useful in treating autoimmune diseases. The therapeutic agents are of the formula X.sup.1 MHC.sup.2 peptide or MHC.sup.2 peptide.sup.1 X wherein X represents a functional moiety selected from a toxin and a labeling group; MHC is an effective portion of the MHC glycoprotein, said glycoprotein dissociated from the cell surface on which it normally resides; and 'peptide' represents an antigenic peptide sequence associated with an autoantigen; .sup.1 represents a covalent bond or a linker bound to X and MHC or to X and peptide by covalent bonds; and .sup.2 represents a covalent bond, a noncovalent association, or a linker covalently bound to or associated with the MHC and peptide. These complexes can be used to target helper T-cells which are specifically immunoreactive with autoantigens.