Company Filing History:
Years Active: 2005-2013
Title: Kristine Holley: Innovator in Epithelial Cell Barrier Modulation
Introduction
Kristine Holley is a prominent inventor based in Boston, MA (US). She has made significant contributions to the field of biomedical research, particularly in the modulation of intercellular junctions. With a total of 5 patents, her work has the potential to impact various therapeutic applications.
Latest Patents
One of her latest patents is titled "Methods and compositions related to the modulation of intercellular junctions." This invention focuses on compositions and methods for modulating the permeability of the epithelial cell barrier complex. It provides innovative approaches using polysaccharides, specifically glycosaminoglycans, and agents that modify cell surface glycosaminoglycans. These methods can facilitate the delivery of biologically active molecules. Another notable patent is "Modified heparinase III and methods of sequencing therewith." This invention relates to heparinase III and its mutants, which have reduced enzymatic activity. These modified forms are useful for various purposes, including the sequencing of heparin-like glycosaminoglycans and inhibiting tumor cell growth.
Career Highlights
Kristine Holley is affiliated with the Massachusetts Institute of Technology, where she continues her research and innovation. Her work has garnered attention for its potential applications in cancer treatment and the modulation of cellular processes.
Collaborations
She has collaborated with notable researchers such as Ram Sasisekharan and Dongfang Liu, contributing to the advancement of her innovative projects.
Conclusion
Kristine Holley's contributions to the field of biomedical research exemplify the impact of innovation in healthcare. Her patents reflect a commitment to advancing scientific knowledge and improving therapeutic strategies.