The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2011
Filed:
Oct. 29, 2008
Dongfang Liu, Yorktown Heights, NY (US);
Kevin Pojasek, Cambridge, MA (US);
Zachary Shriver, Cambridge, MA (US);
Kristine Holley, Boston, MA (US);
Yosuf El-shabrawi, Graz, AT;
Ganesh Venkataraman, Bedford, MA (US);
Ram Sasisekharan, Bedford, MA (US);
Dongfang Liu, Yorktown Heights, NY (US);
Kevin Pojasek, Cambridge, MA (US);
Zachary Shriver, Cambridge, MA (US);
Kristine Holley, Boston, MA (US);
Yosuf El-Shabrawi, Graz, AT;
Ganesh Venkataraman, Bedford, MA (US);
Ram Sasisekharan, Bedford, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.