The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2013
Filed:
Jun. 29, 2005
Aarthi Chandrasekaran, Cambridge, MA (US);
Shiladitya Sengupta, Waltham, MA (US);
David A. Berry, Brookline, MA (US);
Kristine Holley, Boston, MA (US);
Ganlin Zhao, Arlington, MA (US);
Ram Sasisekharan, Bedford, MA (US);
Aarthi Chandrasekaran, Cambridge, MA (US);
Shiladitya Sengupta, Waltham, MA (US);
David A. Berry, Brookline, MA (US);
Kristine Holley, Boston, MA (US);
Ganlin Zhao, Arlington, MA (US);
Ram Sasisekharan, Bedford, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The invention relates to compositions and methods for the modulation of the permeability of the epithelial cell barrier complex. In particular, the invention provides compositions and methods for using polysaccharides, preferably glycosaminoglycans, and agents that modify cell surface glycosaminoglycans, preferably glycosaminoglycan-degrading enzymes to modulate intercellular junctions. The compositions and methods provided can be used to facilitate the delivery of biologically active molecules.