Kristen Naegle

Title: Kristen Naegle: Innovator in Medical Research

Introduction

Kristen Naegle is a prominent inventor based in St. Louis, MO (US). She has made significant contributions to the field of medical research, particularly in the area of patient response to sodium channel blockers and the production of post-translationally modified proteins. With a total of 2 patents, her work has the potential to impact patient care and protein production methodologies.

Latest Patents

One of her latest patents is titled "Predicting patient response to sodium channel blockers." This patent discloses a method for predicting how a patient with LQT syndrome or an arrhythmia will respond to sodium ion channel blockers, such as mexiletine. The method involves determining various parameters associated with sodium ion channels, generating a model for patient response using partial least squared (PLS) regression analysis, and utilizing this model to predict patient responses to treatment.

Another significant patent is the "Toolkit for the production of post-translationally modified proteins." This patent provides a system designed to produce soluble, folded, and post-translationally modified proteins. The system includes a fusion protein that comprises a catalytic domain of an enzyme involved in post-translational protein modification and a targeting domain. Additionally, it features a substrate protein that includes a protein of interest and a sequence that interacts with the targeting domain.

Career Highlights

Kristen has worked with esteemed institutions such as Washington University and Istituti Clinici Scientifici Maugeri Spa Sb. Her experience in these organizations has allowed her to collaborate with leading experts in her field and contribute to groundbreaking research.

Collaborations

Some of her notable coworkers include Jonathan R Silva and Wandi Zhu. Their collaborative efforts have further advanced the research and development of innovative medical solutions.

Conclusion

Kristen Naegle's contributions to medical research through her patents and collaborations highlight her role as an influential inventor. Her work continues to pave the way for advancements in patient care and protein production.