The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2024
Filed:
Dec. 09, 2019
Washington University, St. Louis, MO (US);
Istituti Clinici Scientifici Maugeri Spa SB, Castel Goffredo, IT;
Jonathan Silva, St. Louis, MO (US);
Wandi Zhu, St. Louis, MO (US);
Silvia Priori, St. Louis, MO (US);
Andrea Mazzanti, St. Louis, MO (US);
Kristen Naegle, St. Louis, MO (US);
Washington University, St. Louis, MO (US);
Istituti Clinici Scientifici Maugeri SpA SB, Castel Goffredo MN, IT;
Abstract
Disclosed herein is a method for predicting a patient response to a sodium ion channel blocker such as mexiletine when the patient has LQT syndrome or an arrhythmia. The method generally comprises determining a plurality of parameters associated with sodium ion channels; generating a model for patient response by using a partial least squared (PLS) regression analysis on said plurality of parameters; and using the model to predict the patient response if the patient is administered a sodium ion channel blocker such as mexiletine.