Company Filing History:
Years Active: 2014
Title: Innovations by Krishnamurthy Venkatesan
Introduction
Krishnamurthy Venkatesan is a notable inventor based in Tamil Nadu, India. He has made significant contributions to the field of biotechnology, particularly in the area of protein purification and glycosylation reduction. With a total of 2 patents to his name, Venkatesan's work has the potential to impact various applications in medicine and pharmaceuticals.
Latest Patents
Venkatesan's latest patents include a method for obtaining a purified, biologically active heterologous protein. This invention focuses on the separation and purification of impurities to yield a product that is devoid of related impurities or contains minimal quantities of glycosylated impurities. Specifically, it addresses the identification of glycosylated forms of insulin analogues, such as glargine impurities, characterized post-expression in yeast-based systems. The invention also outlines methods for cloning the gene encoding the protein insulin glargine, inserting it into a suitable yeast host, and producing a culture of the recombinant strain. This process includes stimulating the expression of the heterologous polypeptide, its secretion, and purification post-fermentation.
Another significant patent by Venkatesan is a method for reducing glycosylation of proteins, processes, and proteins thereof. This disclosure relates to reducing O-glycosylation levels of insulin or insulin analog precursor molecules produced by specific yeast strains. The invention provides genetically engineered knock-out strains of methylotrophic yeast, particularly by disrupting Protein mannosyl transferase (PMT) genes. These PMT inactivated strains have been deposited at MTCC, Chandigarh, and include strains such as PMT1/GS115 (MTCC 5515) and PMT4/GS115 (MTCC 5516).
Career Highlights
Krishnamurthy Venkatesan is currently associated with Biocon Limited, a leading biopharmaceutical company. His work at Biocon has allowed him to explore innovative solutions in biotechnology and contribute to advancements in protein engineering.
Collaborations
Venkatesan has collaborated with notable colleagues, including Nitesh Dave and Mukesh Babuappa Patale. These collaborations have fostered a productive environment for research and development in their respective fields.
Conclusion
Krishnamurthy Venkatesan's
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.