Kou-ichi Jishage

Title: Innovations and Contributions of Kou-ichi Jishage

Introduction

Kou-ichi Jishage is a notable inventor based in Shizuoka, Japan. He has made significant contributions to the field of biotechnology, particularly in the development of methods related to human tissue factors and antibody production. With a total of 7 patents to his name, Jishage's work has had a profound impact on medical research and therapeutic applications.

Latest Patents

Among his latest patents, Jishage has developed methods for using human tissue factor-producing knock-in mice. This invention involves a non-human animal that produces human tissue factor (TF) without substantially producing non-human animal tissue factor. The animal's genome has been modified to insert cDNA encoding human TF upstream of the translation initiation codon for the non-human animal genomic TF gene. Additionally, he has created methods for producing antibodies, which include administering an immunogen comprising both a target antigen and a background antigen to transgenic animals. This innovative approach allows for the efficient production of antibodies to target antigens by inducing immunotolerance to the background antigens in the transgenic animals.

Career Highlights

Throughout his career, Kou-ichi Jishage has worked with prominent companies, including Chugai Seiyaku Kabushiki Kaisha. His expertise in biotechnology has enabled him to contribute to various research projects and advancements in the field.

Collaborations

Jishage has collaborated with esteemed colleagues, including Tatsuhiko Kodama and Nobuo Kamada. These partnerships have further enhanced his research and innovation efforts.

Conclusion

Kou-ichi Jishage's contributions to biotechnology through his patents and collaborations highlight his role as a significant inventor in the field. His work continues to influence advancements in medical research and therapeutic solutions.