Location History:
- Gotemba, JP (2018 - 2021)
- Shizuoka, JP (2023)
Company Filing History:
5 out of 950 
2 out of 55 
2 out of 7 
Years Active: 2018-2023
Title: **Koichi Jishage: Innovator in Genetically Modified Animals**
Introduction: Koichi Jishage, based in Gotemba, Japan, is a notable inventor with five patents to his name. His innovations primarily focus on genetically modified non-human animals, which have significant implications for therapeutic applications and drug evaluation.
Latest Patents: Jishage's most recent patents showcase cutting-edge advancements in biotechnology. One of his key inventions is a gene-modified mouse expressing human GPC3 polypeptide. This invention includes genetically modified animals that are deficient in endogenous GPC3 polypeptide and instead express a human variant adequately. His methods facilitate producing these animals and evaluating test substances for safety, therapeutic effects on diseases, pharmacokinetics, and in vivo distribution.
Another notable patent involves non-human animals harboring a human CD3 gene substituted for their endogenous CD3 gene. These genetically modified animals lack multiple types of endogenous CD3 genes and are capable of functionally expressing human CD3 genes. This advancement allows for mature T cell differentiation and the functioning of immunocompetent cells, enabling efficient drug evaluation and therapeutic methods using human CD3-mediated targeted drugs.
Career Highlights: Throughout his career, Koichi Jishage has contributed significantly to medical science, particularly through his involvement with Chugai Pharmaceutical Co., Ltd. and the Tokyo Metropolitan Institute of Medical Science. His work has been pivotal in advancing the understanding and application of genetic modifications in non-human models.
Collaborations: Jishage has collaborated with esteemed professionals such as Otoya Ueda and Michinori Kohara. These partnerships have fostered innovative approaches in the field of biotechnology, contributing to the development of novel therapeutic strategies.
Conclusion: Koichi Jishage stands out as a prominent inventor in the domain of genetic engineering. His patents not only highlight the potential of genetically modified animals in research but also pave the way for more effective therapeutic innovations. As the landscape of biotechnology continues to evolve, Jishage’s contributions will undoubtedly play a crucial role in future advancements.