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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11793180 B1

PDFFull Text
Date of Patent:
Oct. 24, 2023

Filed:

Aug. 21, 2017

Gene-modified mouse expressing human gpc3 polypeptide

Applicant:

Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;

Inventors:

Koichi Jishage, Shizuoka, JP;

Hiroshi Hino, Shizuoka, JP;

Takahiro Ishiguro, Tokyo, JP;

Yasuko Kinoshita, Kanagawa, JP;

Assignee:

Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;

Attorney:

Nixon & Vanderhye P.C.

Primary Examiner:

Anoop K Singh

Int. Cl.
CPC ...
A01K 67/027 (2006.01); C12N 15/85 (2006.01); G01N 33/50 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C12N 5/10 (2006.01); C07K 14/705 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0278 (2013.01); C07K 14/705 (2013.01); C07K 16/2809 (2013.01); C07K 16/303 (2013.01); C12N 5/10 (2013.01); C12N 15/85 (2013.01); G01N 33/5041 (2013.01); G01N 33/5088 (2013.01); A01K 2217/052 (2013.01); A01K 2217/072 (2013.01); A01K 2217/206 (2013.01); A01K 2227/105 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01); C12N 2015/8518 (2013.01);
Abstract

Genetically modified non-human animals which are deficient in expression of an endogenous GPC3 polypeptide and express a human GPC3 polypeptide at a physiologically adequate level; methods for producing the non-human animals; and methods for evaluating test substances using the non-human animals. Furthermore, methods for evaluating test substances regarding their safety, therapeutic effects on diseases, pharmacokinetics, in vivo distribution, and such, using the non-human animals as models.

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Jishage, Koichi. (2023). Gene-modified mouse expressing human gpc3 polypeptide (U.S. Patent No. 11793180). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11793180

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